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The International Journal of the Royal Society of Thailand
Volume XI - 2019

It is worth noting that the genome of CoVs is a single-stranded positive-
sense RNA (++ssRNA) (-30kb) with 5 cap structure and 3’-poly-A tail. The genome
RNA is used as a template to directly translate polyprotein 1a/1ab (pp1a/pp1ab),

which encodes non-structural protein (nsps) to form the replication-transcription
complex (RTC) in a double-membrane vesicles (DMVs).

While waiting for the development of absolutely effective drugs and
vaccines to cope with the current situation, the best measures at the moment
are to control the source of infection, making early diagnosis, requiring strict
isolation of infected cases, and giving supportive treatment.

Acknowledgements
This article is written from information retrieved almost entirely from via

the Google searches, especially the CDC situation summary of Coronavirus
Disease 2019, and from the paper entitled Emerging coronaviruses: Genome
structure, replication, and pathogenesis published by Yu Chen, Qianyun Liu
and Deyin Guo in J Med Virol 2020; 92:418-423, which contains valuable
information from extensive reviewing of 70 published articles

Additional Readings

1. Bovonkitti S. Correct pronunciation of the acronym MERS. Thammasat
Med J 2015; 15: 530.

2. Songsivillai S, Bovornkitti S. Tuberculosis Vaccines. Buddhachinaraj
Med J 2019; 36: 149-52.
3. Bovornkitti S. Brain Vaccine. Thammasat Med J 2020; 20: in print.

4. Phuvitayakamee S, Bovornkitti S. Malaria Vaccine. Thammasat Med J
2020; 20:in print.

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