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158 The Journal of the Royal Institute of Thailand Volume III - 2011 158 Quinine and Quin-Ghao, Natureûs Two Most Important Anti-malarial Drugs Figure 4. The treatment of malaria with qinghao was first recorded in Handbook of Prescriptions for Emergency Treatment by Ge Hong (281-340 AD) (http://www.cultural-china.com/) Figure 5. Clinical trial sites of severe malaria comparing intravenous quinine and artesunate (Dondorp et al, 2005, 2010) 150-159_mac9 5/10/12, 10:06 PM 158