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«“√ “√ √“™∫— ≥±‘µ¬ ∂“π ªï ∑’Ë Ú˜ ©∫— ∫∑’Ë Ò ¡.§.-¡’ .§. ÚıÙı Õ”π«¬ ∂‘ ∞“æ— π∏å ÒÚÛ inheritance) Õ’ °¥â «¬. «‘ ∏’ °“√√— °…“ „π¢≥–π’È ‡ªì π∑’Ë πà “¬‘ π¥’ «à “°”≈— ß®– ¡’ «‘ ∏’ °“√√— °…“‚√§°≈‘ Ë πµ— «‡À¡Á π ∑’ Ë ∂Ÿ ° À≈— °«‘ ™“°“√¬‘Ë ß¢÷È π °≈à “«§◊ Õ æ¬“¬“¡ ≈¥Õ“À“√∑’Ë ®–∂Ÿ °√à “ß°“¬¥Ÿ ¥´÷ ¡·≈â « ‡ª≈’Ë ¬π‡ªì π TMA. Õ“À“√¥— ß°≈à “« ‰¥â ·°à ª≈“‡§Á ¡ ‡π◊È Õ — µ«å ∂—Ë «‡À≈◊ Õß ·≈–‰¢à ‡ªì πµâ π, ‡æ√“–Õ“À“√‡À≈à “π’ È ®–∂Ÿ °·∫§∑’ ‡√’ ¬„π∑“߇¥‘ πÕ“À“√ ‡ª≈’Ë ¬π‰ª‡ªì π‚¶≈’ π, §“√å π‘ ∑’ π ·≈– Smith RL. The Fish-odour syn- drome: Biochemical, familial and clinical aspect. Br Med J 1993; 307: 655-7. Ù. Brand JM, Galask SP. Trimethy- lamine - the substance mainly re- sponsible for the fish odor often as- sociated with bacterial vaginosis. Obstet Gynecol 1986; 68: 682-5. ı. Cashman JR, Bi YA, Lin J, Youil R, Forrest SM, Treacy EP. Human fla- vin-containing monooxygenase: cDNA expression of the structural mutations responsible for trimethy- laminuria. Chem Res Toxicol 1997; 10: 837-41. ˆ. Cashman JR, Akerman BR, Forrest SM, Treacy EP. Population-specific polymorphisms of the human FMO3 gene: significance for detoxication. Drug Metab Disp 2000; 28: 169-73. ˜. Cholerton S, Smith RL. Human phar- macogenetics of nitrogen oxidations. In: Hlavica P, Damani LA, editors. N-oxidation of drugs-biochemistry, pharmacology, toxicology. London: Chapman & Hall; 1991. p. 107-31. ¯. Dolphin CT, Janmohamed A, Smith RL, Shephard EA, Phillips IR. Mis- sense mutation in flavin-containing monooxygenase 3 gene, FMO3, un- derlines fish-odor syndrome. Nat Genet 1997; 17: 491-4. ˘. Forrest SM, Knight M, Akerman BR, Cashman JR, Treacy EP. A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuria. Pharmacogenetics 2001; 11: 169-74. Ò. Hadidi HF, Cholerton S, Atkinson S, Irshaid YM, Rawashdeh NM, Idle JR. The N-oxidation of trimethylamine in a Jordanian population. Br J Clin Pharmacol 1995; 39: 179-81. ÒÒ. Humbert JR, Hammond KB, Hathaway WE, Marcoux JG, OûBrien D. Trimethylaminuria: the fish-odor syndrome. Lancet 1970; 1: 770-1. ÒÚ. Lang DH, Yeug CK, Peter RM, Ibarra C, Gasser R, Itagaki K, et al. Isoform ∫’ ‡∑π, ·≈–„π∑’Ë ÿ ¥‡ªì π TMA. à «π °“√√— °…“Õ’ °«‘ ∏’ Àπ÷Ë ß°Á §◊ Õ°“√„™â ¬“ µâ “π®ÿ ≈™’ ææ«°‡¡‚∑√π‘ ¥“‚´≈ ‰ª ¬— ∫¬—È ß°“√∑”ß“π¢Õß·∫§∑’ ‡√’ ¬¥— ß °≈à “«. ·µà «‘ ∏’ À≈— ßπ’È Õ“®‡ ’Ë ¬ßµà Õ°“√ ·æâ ¬“ À√◊ Õ°“√‡°‘ ¥º≈¢â “߇§’ ¬ß®“°¬“. «‘ ∏’ ∑’Ë ¥’ ∑’Ë ÿ ¥∑’Ë À≈ “¬ ∂“∫— π°”≈— ß æ— ≤π“Õ¬àŸ „π¢≥–π’È °Á §◊ Õ æ— π∏ÿ °√√¡ ∫”∫— ¥ (gene therapy) ‚¥¬°“√ µ— ¥µà ÕÀπà «¬æ— π∏ÿ °√√¡ (®’ π) ‡æ◊ Ë Õ‡√à ß „Àâ √à “ß°“¬ “¡“√∂º≈‘ µ FMO 3 „Àâ ∑”ß“π‰¥â ‡™à πª√°µ‘ . √Ÿ ª∑’ Ë Ò “‡Àµÿ ¢Õß°“√‡°‘ ¥‚√§°≈‘Ë πµ— «‡À¡Á π ·≈–°≈«‘ ∏“π°“√ÕÕ°ƒ∑∏‘Ï ¢Õ߬“. ¬“°≈à Õ¡ª√– “∑ ¬“µâ “π®ÿ ≈™’ æ ¬“§≈“¬‡§√’ ¬¥ ¶à “ ¬— ∫¬— È ß ·∫§∑’ ‡√’ ¬ ‡Õπ´— ¬¡å FM0 3 Õ“À“√ TMA TMA - O (‰¢à ‡π◊È Õ — µ«å ∂—Ë «‡À≈◊ Õß (°≈‘Ë πª≈“‡πà “) (‰¡à ¡’ °≈‘Ë π) ·≈–ª≈“∑–‡≈) fish-malodor syndrome (ªí “«– ≈¡À“¬„® ‡Àß◊Ë Õ ¡’ °≈‘Ë πª≈“‡πà “) ∫√√≥“πÿ °√¡ Ò. Akerman BR, Forrest S, Chow L, Youil R, Knight M, Treacy EP. Two novel mutations of the FMO3 gene in a proband with trimethylaminuria. Hum Mutat 1999; 13: 376-9. Ú. Al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. A genetic poly- morphism of the N-oxidation of tri- methylamine in humans. Clin Pharmacol Ther 1987; 42: 588-94. Û. Ayesh R, Mitchell SC, Zhang AQ,