สำนักราชบัณฑิตยสภา

The Journal of the Royal Institute of Thailand Vol. 30 No. 3 Jul.-Sep. 2005 646 √–∫∫§«∫§ÿ ¡§«“¡¥— π‡≈◊ Õ¥„π§πª√°µ‘ ‡¡◊Ë Õ§«“¡¥— π‡≈◊ Õ¥≈¥µË ”≈ß ‡≈◊ Õ¥ ®–‰ª¬— ߉µπâ Õ¬≈ß∑”„Àâ ‡°‘ ¥ renal is- chemia ®–‰ª°√–µÿâ π„Àâ juxtaglome- rular cell ´÷Ë ßÕ¬Ÿà ∑’Ë afferent arteriole „°≈â glomerulus „Àâ À≈—Ë ß renin ÕÕ°¡“ ¡“°¢÷È π renin ‡ªì π‡Õπ‰´¡å ®–‰ª¬à Õ¬ angiotensinogen ´÷Ë ß¡’ Õ¬Ÿà ·≈â «„π°√–· ‡≈◊ Õ¥„Àâ ‡ªì π angiotensin I angiotensin converting enzyme ®–¬à Õ¬ angioten- sin I µà Õ‰ª„Àâ ‡ªì π angiotensin II ´÷Ë ß¡’ ƒ∑∏‘Ï ∑”„Àâ À≈Õ¥‡≈◊ Õ¥ à «πª≈“¬À≈Õ¥ ‡≈◊ Õ¥·¥ß®‘Î «À¥µ— « §«“¡¥— π‡≈◊ Õ¥®– Ÿ ß ¢÷È π‡ªì πª√°µ‘ Ú.Ú °“√§«∫§ÿ ¡§«“¡¥— π‡≈◊ Õ¥ ‚¥¬ extracellular fluid volume ·≈– autoregulation ¥— ß√Ÿ ª∑’Ë Ú.Ú √Ÿ ª∑’Ë Ú.Ú Arterial Pressure Falls Renal ischemia Diminished glomerular filtration Water and electrolyte retention Increased extracellular fluid volume Increased blood volume Increased right atrial pressure Increased cardiac output Increased tissue blood flow (Autoregulation) Increased total peripheral resistance Increased Arterial Pressure Relief of renal ischemia ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲ ▲