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The Journal of the Royal Institute of Thailand Vol. 30 No. 4 Oct.-Dec. 2005 1136 Scientific Instrumentation in Research extracts with such hyphenated techniques generates a huge amount of information. In order to rationalise this approach and to use it efficiently with a high sample throughput, the next challenge will be to find a way to centralise all these data for rapid pattern recognition by reference to standard compounds. With such an analytical system, phytochemists will then be able to concentrate their efforts on finding new biological targets. This aspect still remains the more difficult problem to solve when searching for new leads. The recent advances in electronics and computer hardware and software made the today expensive machines highly sophisticated and thus very sensitive and need careful maintenance. We have to look after these expensive machines with “Tender Loving Care” like our children. Moreover these highly sophisticated and sensitive machines often break down like these two quotations. WARNING : THIS MACHINE SUBJECT TO BREAKDOWNS DURING PERIODS OF CRITICAL NEEDS. KEEP COOLAND SAY NICE THINGS TO THE MACHINE: NOTHING ELSE SEEMS TO WORK.