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บิ สฟอสโฟเนตและการตายของกระดูกขากรรไกรบางส่วน 104 The Journal of the Royal Institute of Thailand Vol. 38 No. 3 July-Sep 2013 Abstract Bisphosphonates and Osteonecrosis of the Jaw Chainut Chongrak Associate Fellow of the Academy of Science, The Royal Institute, Thailand The increasing cases of BRONJ has important medical and dental implication. Bisphosphonates using for prevention or treatment of some specific diseases initiates bone sclerosis and deprivation of blood supply. The patients tak- ing intravenous injection bisphosphonates have a higher risk for developing BRONJ while patients taking oral bisphosphonates have a low risk. BRONJ in these patients usually occurs as a non healing socket after tooth extraction or exposed bone in oral cavity more than three weeks after oral surgical management. Dental practitioner may be the one who recognises the disease earlier and thus plays an important role in prevention, treatment and follow up. The patients who are taking or scheduled to recieve bisphosphonates therapy should inform their dentist to prevent complications from dental surgical procedure. Keywords: bisphosphonates, osteonecrosis of the jaw