59-05-032 Proceeding

208 Proceedings of the Princess Maha Chakri Sirindhorn Congress The presence of seizure was inversely correlated to patient survival. Figure 1 depicts the survival curve of SLE patients with or without seizure. Survival was significantly lower in patients with seizure than that in patients without seizure (log rank test p < 0.001). In the univariate analysis, the risk of mortality was statistical significantly associated with age of onset, disease duration, photosensitivity, arthritis, serositis, proteinuria, anemia, leukopenia, lymphopenia, thrombocytopenia, seizure, anti-dsDNApositivity, hypertension, diabetesmellitus, end stage renal disease, and cerebrovascular disease (Table 4). However, gender, other clinical features, and laboratory data did not differ in mortality. Multivariate Cox regression analysis showed that age at admission > 50 years (HR 2.62, 95% CI 1.54 – 4.45, p < 0.001), male (HR 2.36, 95% CI 1.24 – 4.49, p = 0.009), serositis (HR 2.86, 95% CI 1.72 – 4.76, p < 0.001), leukopenia (HR 2.06, 95% CI 1.14 – 3.70, p = 0.016), thrombocytopenia (HR 3.84, 95% CI 2.08 – 7.09, p < 0.001), seizure (HR 1.94, 95% CI 1.12 – 3.35, p = 0.018), and anti-dsDNA positivity (HR 0.43, 95% CI 0.25 – 0.74, p = 0.002), were the predictors for mortality in SLE patients (Table 5) Table 5 Multivariate Cox regression analysis: adjusted hazard ratio for the risk of mortality in 691 SLE patients Hazard ratio 95% CI for HR P-value Onset age > 50 (yrs) 2.62 1.54 – 4.45 < 0.001* Male (%) 2.36 1.24 – 4.49 0.009* Photosensitivity (%) 0.54 0.19 – 1.57 0.259 Arthritis (%) Serositis (%) 1.08 2.86 0.67 – 1.73 1.72 – 4.76 0.766 < 0.001* Figure 1 Survival curves for SLE patients with (n = 72) and without (n = 618) seizure