59-05-032 Proceeding

206 Proceedings of the Princess Maha Chakri Sirindhorn Congress Yes (n=72) No (n=618) P-value aPL (%) 23 (32.0) 191(31.0) 0.781 Comorbidity HTH (%) 30 (41.7) 190 (30.8) 0.061 DM (%) 7 (9.7) 44 (6.5) 0.424 ESRD (%) 17 (23.6) 45 (7.3) < 0.001* CVA (%) 15 (20.8) 40 (6.5) < 0.001* Mortality (%) 27 (37.5) 72 (11.7) < 0.001* C. Multivariate analysis of seizure predictors Several significant factors were selected for logistic regression to identify independent predictive factors for seizure in SLE patients. These factors included gender, onset age more than 50 years old, photosensitivity, proteinuria, leukopenia, lymphopenia, thrombocytopenia, psychosis, end stage renal disease and cerebrovascular disease. Table 3 showed multivariate analysis with adjusted odds ratio for risk of seizure in SLE. Multivariate analysis showed that photosensitivity (OR 2.286, 95% CI 1.26 – 4.15, p = 0.006), proteinuria (OR 2.160, 95% CI 1.24 – 3.77, p = 0.006), leukopenia (OR 2.043, 95% CI 1.21 – 3.44, p = 0.006), thrombocytopenia (OR 2.143, 95% CI 1.30 – 3.53, p = 0.002), psychosis (OR 3.363, 95%CI 2.11 – 7.34, p < 0.001), end stage renal disease (OR3.936, 95%CI 2.11 – 7.34, p< 0.001) and cerebrovascular disease (OR3.803, 95%CI 1.98 – 7.31, p < 0.001) remained the predictive factors for seizure in SLE patients. Table 3 Multivariate analysis: adjusted odds ratio for risk of seizure in SLE Odds ratio 95% CI for OR P-value Male 0.43 0.15 – 1.22 0.104 Onset age > 50 y/o 1.262 0.74 – 2.17 0.397 Photosensitivity 2.286 1.26 – 4.15 0.006* Proteinuria 2.160 1.24 – 3.77 0.006* Leukopenia 2.043 1.21 – 3.44 0.006* Lymphopenia 2.598 1.26 – 5.34 0.007* Thrombocytopenia 2.143 1.30 – 3.53 0.002* Psychosis 3.363 1.70 – 6.67 < 0.001* ESRD 3.936 2.11 – 7.34 < 0.001* CVA 3.803 1.98 – 7.31 < 0.001*